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  <xs:element id="arqt_StockIssuedDuringPeriodLapseOfRepurchaseRightsPursuantToEarlyStockExercises" abstract="false" name="StockIssuedDuringPeriodLapseOfRepurchaseRightsPursuantToEarlyStockExercises" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_IncreaseDecreaseInOperatingLeaseLiabilities" abstract="false" name="IncreaseDecreaseInOperatingLeaseLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_MilestonePaymentForIntangibleAssetIncurredButNotYetPaid" abstract="false" name="MilestonePaymentForIntangibleAssetIncurredButNotYetPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_LicenseAgreementsAndAcquisitionDisclosureAbstract" abstract="true" name="LicenseAgreementsAndAcquisitionDisclosureAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="arqt_UnauditedInterimCondensedFinancialStatementsPolicyPolicyTextBlock" abstract="false" name="UnauditedInterimCondensedFinancialStatementsPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="arqt_CoPromotionAgreementsPolicyPolicyTextBlock" abstract="false" name="CoPromotionAgreementsPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="arqt_SecondaryEquityPublicOfferingMember" abstract="true" name="SecondaryEquityPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_ThirdEquityPublicOfferingMember" abstract="true" name="ThirdEquityPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_FourthEquityPublicOfferingMember" abstract="true" name="FourthEquityPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_FifthEquityPublicOfferingMember" abstract="true" name="FifthEquityPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_AtTheMarketMember" abstract="true" name="AtTheMarketMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_PrefundedWarrantMember" abstract="true" name="PrefundedWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_CowenAndCompanyLLCMember" abstract="true" name="CowenAndCompanyLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_LoanAgreementMember" abstract="true" name="LoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_SaleOfStockPotentialNumberOfSharesToBeIssuedInTransaction" abstract="false" name="SaleOfStockPotentialNumberOfSharesToBeIssuedInTransaction" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="arqt_SaleOfStockAuthorizedConsiderationOnTransaction" abstract="false" name="SaleOfStockAuthorizedConsiderationOnTransaction" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_SaleOfStockAgentFeePercentageOfGrossProceeds" abstract="false" name="SaleOfStockAgentFeePercentageOfGrossProceeds" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="arqt_CashCashEquivalentsAndMarketableSecurities" abstract="false" name="CashCashEquivalentsAndMarketableSecurities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_ZORYVECream0.3Member" abstract="true" name="ZORYVECream0.3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_ZORYVEFoamMember" abstract="true" name="ZORYVEFoamMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_ZORYVECream0.15Member" abstract="true" name="ZORYVECream0.15Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleFairValueDisclosure" abstract="false" name="CashAndCashEquivalentsAndDebtSecuritiesAvailableForSaleFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_CashAndCashEquivalentsUnrealizedGain" abstract="false" name="CashAndCashEquivalentsUnrealizedGain" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_CashAndCashEquivalentsUnrealizedLoss" abstract="false" name="CashAndCashEquivalentsUnrealizedLoss" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_PrepaidCopayAssistanceProgramAndRebates" abstract="false" name="PrepaidCopayAssistanceProgramAndRebates" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_PrepaidClinicalTrialTestCostsCurrent" abstract="false" name="PrepaidClinicalTrialTestCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_AccruedSalesDiscounts" abstract="false" name="AccruedSalesDiscounts" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_ClinicalTrialAccrualCurrent" abstract="false" name="ClinicalTrialAccrualCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_SatoMember" abstract="true" name="SatoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_ContractNotWithCustomerUpfrontPaymentNet" abstract="false" name="ContractNotWithCustomerUpfrontPaymentNet" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_RevenueRemainingPerformanceObligationVariableConsiderationAmount" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_RevenueRemainingPerformanceObligationVariableConsiderationAmountSalesMilestones" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationAmountSalesMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_LicenseAgreementNumberOfYearsAfterFirstCommercialSaleToReceiveRoyalties" abstract="false" name="LicenseAgreementNumberOfYearsAfterFirstCommercialSaleToReceiveRoyalties" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="arqt_LicenseAgreementTerminationNumberOfDaysForWrittenNotice" abstract="false" name="LicenseAgreementTerminationNumberOfDaysForWrittenNotice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="arqt_HuadongMember" abstract="true" name="HuadongMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_ContractNotWithCustomerLiabilityTaxWithholdingObligation" abstract="false" name="ContractNotWithCustomerLiabilityTaxWithholdingObligation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_AstraZenecaMember" abstract="true" name="AstraZenecaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_ResearchAndDevelopmentArrangementUpfrontPayment" abstract="false" name="ResearchAndDevelopmentArrangementUpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" abstract="false" name="TemporaryEquityStockIssuedDuringPeriodSharesNewIssues" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="arqt_ResearchAndDevelopmentArrangementContractToPerformForOthersMilestonePaymentForFirstTrialCompletion" abstract="false" name="ResearchAndDevelopmentArrangementContractToPerformForOthersMilestonePaymentForFirstTrialCompletion" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_ResearchAndDevelopmentArrangementContractToPerformForOthersProductMilestonePaymentForFirstProductApproval" abstract="false" name="ResearchAndDevelopmentArrangementContractToPerformForOthersProductMilestonePaymentForFirstProductApproval" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_ResearchAndDevelopmentArrangementContractToPerformForOthersPaymentsMilestonesFuturePayableAmount" abstract="false" name="ResearchAndDevelopmentArrangementContractToPerformForOthersPaymentsMilestonesFuturePayableAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_ResearchAndDevelopmentArrangementContractToPerformForOthersAnnualWorldwideNetSalesThreshold" abstract="false" name="ResearchAndDevelopmentArrangementContractToPerformForOthersAnnualWorldwideNetSalesThreshold" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_ResearchAndDevelopmentArrangementContractToPerformForOthersMaximumProductMilestonePayments" abstract="false" name="ResearchAndDevelopmentArrangementContractToPerformForOthersMaximumProductMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_ResearchAndDevelopmentArrangementContractToPerformForOthersMaximumSalesMilestonePayments" abstract="false" name="ResearchAndDevelopmentArrangementContractToPerformForOthersMaximumSalesMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_ResearchAndDevelopmentArrangementContractToPerformForOthersMilestonePayment" abstract="false" name="ResearchAndDevelopmentArrangementContractToPerformForOthersMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_DebtInstrumentTrancheAxis" abstract="true" name="DebtInstrumentTrancheAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="arqt_DebtInstrumentTrancheDomain" abstract="true" name="DebtInstrumentTrancheDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_TrancheATermLoanMember" abstract="true" name="TrancheATermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_TrancheB1TermLoanMember" abstract="true" name="TrancheB1TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_TrancheB2TermLoanMember" abstract="true" name="TrancheB2TermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_LoanAgreementTrancheC1ExpiringMarch312026Member" abstract="true" name="LoanAgreementTrancheC1ExpiringMarch312026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_LoanAgreementTrancheC2ExpiringJune302026Member" abstract="true" name="LoanAgreementTrancheC2ExpiringJune302026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_TrancheCTermLoanMember" abstract="true" name="TrancheCTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="arqt_DebtInstrumentPrepaymentPremium" abstract="false" name="DebtInstrumentPrepaymentPremium" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="arqt_DebtInstrumentMaximumBorrowingCapacity" abstract="false" name="DebtInstrumentMaximumBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_DebtInstrumentPrepaymentPenalty" abstract="false" name="DebtInstrumentPrepaymentPenalty" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_DebtInstrumentFundingAvailabilityCovenantPeriod" abstract="false" name="DebtInstrumentFundingAvailabilityCovenantPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="arqt_DebtInstrumentCovenantMinimumNetProductRevenueAsAPercentageOfProjectedNetProductRevenue" abstract="false" name="DebtInstrumentCovenantMinimumNetProductRevenueAsAPercentageOfProjectedNetProductRevenue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="arqt_DebtInstrumentInterestRateStatedPercentagePartialPrepayment" abstract="false" name="DebtInstrumentInterestRateStatedPercentagePartialPrepayment" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="arqt_DebtInstrumentInterestRateAtPeriodEnd" abstract="false" name="DebtInstrumentInterestRateAtPeriodEnd" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="arqt_DebtInstrumentDefaultRate" abstract="false" name="DebtInstrumentDefaultRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="arqt_DebtInstrumentFinalFeePercentage" abstract="false" name="DebtInstrumentFinalFeePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="arqt_DebtInstrumentExtensionFeePercentage" abstract="false" name="DebtInstrumentExtensionFeePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="arqt_DebtInstrumentExitFeeExpirationPeriod" abstract="false" name="DebtInstrumentExitFeeExpirationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="arqt_DebtInstrumentDeferredFinalFeeGross" abstract="false" name="DebtInstrumentDeferredFinalFeeGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_DebtInstrumentAccruedFinalFee" abstract="false" name="DebtInstrumentAccruedFinalFee" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="arqt_StockOptionExchangeMember" abstract="true" name="StockOptionExchangeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_FirstGrantDateMember" abstract="true" name="FirstGrantDateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_SecondGrantDateMember" abstract="true" name="SecondGrantDateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_ThirdGrantDateMember" abstract="true" name="ThirdGrantDateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="arqt_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfEligibleOptionsExchanged" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfEligibleOptionsExchanged" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="arqt_EarlyExercisedOptionsMember" abstract="true" name="EarlyExercisedOptionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
